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Short CV
EDUCATION
- Barend C B Bezuidenhoudt obtained his M.Sc. (with distinction) form the University of the Orange Free State in 1977 under the guidence of the late Prof DG Roux and his Ph.D. in 1985 with Prof D Ferreira as promotor.
- During 1988 he spend a year as Post-doctoral Research Fellow in the Synthetic Organic Chemistry group of Prof AGM Barrett at Northwestern University in Evanston, Illinois, USA.
- A four month sabbatical was also spent as Research Fellow in the Synthetic Organic Chemistry group of Prof SV Ley at Cambridge University, Cambridge, UK during the first part of 1994.
- During 1999 he completed the Programme in Engineering Management at the University of Pretoria’s Business school.
ACADEMIC POSITIONS at the University of the Orange Free State’s Chemistry Department
1977 - 1978 Research Assistant in the CSIR's Flavonoid Research Unit.
1979 - 1985 Lecturer in Organic Chemistry
1986 - 1994 Senior Lecturer in Organic Chemistry
1995 - 1996 Associate Professor in Organic Chemistry
2006 - Sasol Professor of Organic Chemistry
POST-GRADUATE STUDENT SUPERVISION
Current research group:
Post-doc: 2
Ph.D. students: 5
M.Sc. students: 2
Degrees awarded:
(i) as co-supervisor: 9 M.Sc. - and 2 Ph.D. students.
(ii) as supervisor: 18 M.Sc. - and 3 Ph.D. students
INDUSTRIAL POSITIONS at Sasol Technology Ltd
1996 - 1999 Principal Scientist
1999 - 2006 Chief Scientist
2006 - Senior Chief Scientist
RESEARCH INVOLVEMENT AT SASOL
Phase 1 - Groupleader of ca 5 researchers (1996 – 1999)
Catalytic distillation technology and development of acrylamide/polyacrylamide production technology.
Production of TEB from crotonaldehyde and ethanol (plant commisioned).
Phase 2 - Line Manager for 10 - 13 researchers (2000 – 2005)
Merisol support regarding technology for the production of down stream products from phenols and cresols.
Establishment of a Ligand Synthesis group and joint development of the novel Sasol Ethylene Tetramerisation technology.
AWARDS AND ACHIEVEMENTS
1994: C1 Rating - FRD
1998: Stars of the Year award – Sasol Technology R & D.
2000: Silver Innovation Award of the SA Institute of Chemical Engineers.
RESEARCH OUTPUTS
1. Papers in International Chemistry Journals: 62
2. Patents and Provisional Patents: 7
3. Conference contributions: 48 of which 2 as invited speaker.
CURRENT RESEARCH INTERESTS
· Methodology development for the synthesis of Flavonoids.
· Stereoselective synthesis of Flavonoids.
· Improved methodology for current industrial processes.
· Oxidation chemistry aimed at the production of oxygenated products from alkenes.
· Application of MALDI-TOF MS to the characterisation of organometallic catalysts in solution. Area of ExpertiseOrganic Synthesis
Industrial Process Chemistry
Natural Products Publications (Short List) Recent Papers
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2006
54. The HF/BF3 Catalysed Reaction of Substituted Benzenes with Carbon Monoxide.
JA Willemse, BCB Bezuidenhoudt, and CW Holzapfel, Synthesis, 2006, 2006, 2543.
2007
55. Borate Esters as Alternative Acid Promoters in the Palladium-catalysed Methoxy-carbonylation of Ethylene.
AC Ferreira, R Crous, L Bennie, AMM Meij, K Blann, BCB Bezuidenhoudt, DA Young, MJ Green, and A Roodt, Angew. Chem. Int. Ed. Eng., 2007, 46(13), 2273.
56. Two new Promelacacinidin dimers including a novel Flavanone-flavanol dimer characterised by a unique C(3)-C(4) linkage, from the heartwood of Acacia nigrescens.
H Howell, E Malan, DJ Brand, BI Kamara, BCB Bezuidenhoudt, C Marais, and JA Steenkamp, Chem. of Nat. Compounds, 2007, 43(5), 533.
2008
57. Studies towards the Stereoselective α-Hydroxylation of Flavanones. Biosynthetic Significance.
Z-M Border, C Marais, BCB Bezuidenhoudt, and JA Steenkamp, Aust. J. Chem., 2008, 61, 122.
58. Tetrakis(2-2-methylbenzoato)-bis(2-methylbenzoic acid)-di-copper(II).
AC Sunil, BCB Bezuidenhoudt, and JM Janse van Rensburg, Acta Cryst. Section E, 2008, E64, m553.
59. Tetrakis(2-4-ethylbenzoato)-bis(4-ethylbenzoic acid)-di-copper(II).
AC Sunil, BCB Bezuidenhoudt, and JM Janse van Rensburg, Acta Cryst. Section E, 2008, E64(7), m939
2009
60. Tricarbonyl(η6-4_,7-dimethoxyisoflavone)chromium(0).
JH van Tonder, BCB Bezuidenhoudt, and JM Janse van Rensburg, Acta Cryst. Section E, 2009, E65, m1343.
61. Tricarbonyl(η6-flavone)chromium(0).
JH van Tonder, BCB Bezuidenhoudt, and JM Janse van Rensburg, Acta Cryst. Section E, 2009, E65, m1346.
2010
62. Conversion of pravastatin into an advanced intermediate for the synthesis of the HMG-CoA reductase inhibitor BB-476.
JJC Grove, PS van Heerden, D Ferreira, and BCB Bezuidenhoudt, Tetrahedron Lett., 2010, 51, 57. (DOI: 10.1016/j.tetlet.2009.10.080.)
62. Regioselective Hydrogenation of a,b-Unsaturated Ketones over Wilkinson’s catalyst.
JH van Tonder, C Marais, DJ Cole-Hamilton, and BCB Bezuidenhoudt. Synthesis, 2010, (3), 421.
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