
The Advanced Biomolecular Research cluster brings together expertise from various disciplines to synergize in the study of biological systems in a high throughput manner, often at the level of the whole genome or proteome.
Disciplines that are directly involved in the research activities include biochemistry, molecular biology, microbiology, virology, statistics, mathematics and computer science. The cluster does not limit the scope of research questions that can be asked within the cluster, but rather provides an opportunity to address biological questions in a manner that provides a far more definitive answer than that of a classic biological approach.
Although the cluster incorporates several focus areas, these areas are interdependent, and activities in the one focus area will require support from one or more of the other focus areas.
Our latest publications:
- Ngubo, M, Kemp, G and Patterton, HG (2011) Nano-electrospray tandem mass spectrometric analysis of the acetylation state of histones H3 and H4 in stationary phase in Saccharomyces cerevisiae. BMC Biochemistry, 12, 34.
- du Preez, LL and Patterton, HG Secondary structures of the core histone N-terminal tails: their role in regulating chromatin structure in Kundu, T and Dasgupta S (eds.) Epigenetics: Disease and Development. Springer, New York, 2011.
- Mayne SLN and Patterton HG (2011) Bioinformatics tools for the structural elucidation of multi-subunit protein complexes by mass spectrometric analysis of protein–protein cross-links. Brief. Bioinform. (doi:10.1093/bib/bbq087)
- Gudiminchi RK and Smit MS (2010) Identification and characterization of 4-hexylbenzoic acid and 4-nonyloxybenzoic acid as substrates of CYP102A1. Appl. Microbiol Biotechnol. (doi:10.1007/s00253-010-3029-x)